DETECTING GASTROINTESTINAL NEOPLASMS

摘要

Provided herein is technology for gastrointestinal neoplasia screening and particularly, but not exclusively, to methods, compositions, and related uses for detecting the presence of gastrointestinal neoplasm, and classifying the site location of such a gastrointestinal neoplasm (e.g., a colorectal region, a pancreaticobiliary region, a gastroesophageal region).

主权项

1. A method of classifying lower gastrointestinal neoplasm and upper gastrointestinal neoplasm in a sample obtained from a subject having gastrointestinal neoplasm, the method comprising:
1) assaying a methylation state of a marker in a sample obtained from the subject; and 2) classifying the subject as having lower gastrointestinal neoplasm when the methylation state of the marker is similar to a methylation state of the marker assayed in a subject that has a lower gastrointestinal neoplasm, 3) classifying the subject as having upper gastrointestinal neoplasm when the methylation state of the marker is similar to a methylation state of the marker assayed in a subject that has an upper gastrointestinal neoplasm, wherein the marker comprises a base in a differentially methylated region (DMR) selected from a group consisting of DMR No. 1 and 5 as provided in Table 1.