发明名称 Use of benzylideneaminoguanidines and hydroxyguanidines as melanocortin receptor ligands
摘要 The present invention relates to the use of compounds of general formula (I) as ligands to the melanocortin receptors and/or for treatment of disorders in the melanocortin system: wherein X is H or OH; R1, R2, R3, R4 and R5 are the same or different and are selected from hydrogen, halogen, alkyl having 1 to 5 carbon atoms, electron donor groups such as alkoxy having 1-5 carbon atoms or hydroxy, electron acceptor groups selected from cyano, nitro, trifluoroalkyl or amide; alkylamino, benzoyloxy, nitroxy, phenyl or sulpho; and the pharmacologically active salts thereof.
申请公布号 US2007088085(A1) 申请公布日期 2007.04.19
申请号 US20060639190 申请日期 2006.12.15
申请人 MELACURE THERAPEUTICS AB 发明人 LUNDSTEDT TORBJORN;SKOTTNER ANNA;SEIFERT ELISABETH
分类号 A61K31/205;C07D317/58;A61K8/00;A61K8/43;A61K31/155;A61K31/185;A61K31/275;A61K31/36;A61K51/00;A61P1/04;A61P1/14;A61P1/16;A61P1/18;A61P3/00;A61P3/04;A61P3/06;A61P3/10;A61P5/00;A61P5/06;A61P5/10;A61P5/14;A61P5/30;A61P5/40;A61P7/00;A61P7/02;A61P7/04;A61P7/06;A61P7/08;A61P7/10;A61P9/00;A61P9/02;A61P9/04;A61P9/06;A61P9/08;A61P9/10;A61P9/12;A61P9/14;A61P11/00;A61P11/02;A61P11/06;A61P13/12;A61P15/00;A61P15/04;A61P15/06;A61P15/08;A61P15/10;A61P17/00;A61P17/02;A61P17/04;A61P17/06;A61P17/08;A61P17/16;A61P19/02;A61P19/04;A61P25/00;A61P25/02;A61P25/04;A61P25/18;A61P25/22;A61P25/24;A61P25/28;A61P25/32;A61P25/36;A61P27/02;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P33/02;A61P33/10;A61P35/00;A61P35/04;A61P37/02;A61P37/04;A61P37/06;A61P37/08;A61P39/00;A61P39/02;A61P43/00;A61Q17/04;A61Q19/00;A61Q19/02;C07D317/62 主分类号 A61K31/205
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