Molecular constructs for treating central nervous system diseases

摘要

The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.

主权项

1. A molecular construct comprising,
a pair of CH2-CH3 segments of an IgG.Fc; a pair of effector elements, wherein each effector element is interferon β1a (INF-β1a) or INF-β1b, or an antibody fragment specific for integrin α4 or β-amyloid; and a pair of targeting elements, wherein each targeting element is an antibody fragment specific for human transferrin receptor or human insulin receptor, wherein, when the pair of effector elements is linked to the N-termini of the pair of CH2-CH3 segments, then the pair of targeting elements is linked to the C-termini of the pair of CH2-CH3 segments, and vice versa, or when the pair of effector elements and the pair of targeting elements are both in the form of single-chain variable fragments (scFvs), then the pair of targeting elements is linked to the N-termini of the pair of effector elements in a tandem or diabody configuration, thereby forming a pair of bispecific scFvs that are linked to the N-termini of the pair of CH2-CH3 segments.