发明名称 |
Process for the preparation of a 2-oxopyrrolidine compound |
摘要 |
A process for producing a lactam of the formula wherein 2-bromo-4 chloro butyryl bromide or 2,4-dibromo butyryl bromide is coupled with 4-aminobenzonitrile to produce 4-(2,4-bromobutyrylamino)-benzonitrile, which is combined with sodium hydroxide, potassium hydroxide or potassium carbonate to produce 4-(3-bromo-2-oxopyrrolidin-1-yl)benzonitrile which is subjected to an excess of ammonium hydroxide to produce compounds of the formula (I).
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申请公布号 |
US5986107(A) |
申请公布日期 |
1999.11.16 |
申请号 |
US19990261303 |
申请日期 |
1999.03.02 |
申请人 |
G. D. SEARLE & CO. |
发明人 |
COLSON, PIERRE-JEAN;BABIAK, KEVIN A.;KORTE, DONALD E.;PRZYBYLA, CLAIRE A.;SEANEY, LISA M.;WISE, BRUCE E. |
分类号 |
C07D207/26;C07D207/273;(IPC1-7):C07D207/14 |
主分类号 |
C07D207/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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