DETECTION OF PROSTATE CANCER USING PSA GLYCOSYLATION PATTERNS

摘要

The present invention features novel methods for determining if a subject has prostate caner. The present invention is based on the development of lectin immunosorbant assays which analyze a2,6-linked sialylation of total serum PSA by sambucus nigra lectin (SNA) and a2,3 -linked sialylation of total and free serum PSA. These novel assays were used then to conduct a clinical investigation of the potential role of glycoprotein analysis in improving PSA's cancer specificity. The present invention also features kits for determining if a subject has prostate cancer comprising one or more lectins and a PSA specific antibody and instructions for use.