| 主权项 |
1. A non-covalent derivative (NCD) of a compound of Formula I with a ligand: wherein: M is Fe, Zn or Cu; R1 and R2 are each independently selected from the group consisting of H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, substituted or unsubstituted C5-C10 aryl, substituted or unsubstituted C5-C10 heteroaryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted —C1-C6 alkyl-C6-C10 aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, —C1-C6 alkyl-heterocyclyl, substituted or unsubstituted C1-C6 alkylC(O)—, substituted or unsubstituted C1-C6alkylS(O)1-2—, substituted or unsubstituted C1-C6alkylNR′C(O)— and substituted or unsubstituted C1-C6 alkoxyC(NR″)—, hydroxy, hydroxyalkyl, alkoxy, —NH(R7), —N(R7)2, —COOH, —COR7, —COOR7, —CONHR7, —CSNHR7, —S(O)R7, —S(O)2R7, —C(O)N(R7)2, —SO2N(R7)2 and —(CH2)mR8, each of which may be optionally substituted; or R1 and R2 when taken together with the nitrogen atom to which they are attached form an optionally substituted heterocycloalkyl or heteroaryl group; R3 and R4 are each independently H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C1-C6 alkynyl, substituted or unsubstituted C1-C6 heteroalkyl, substituted or unsubstituted C3-C10 cycloalkyl, substituted or unsubstituted C3-C10 heterocycloalkyl, substituted or unsubstituted C5-C10 aryl, substituted or unsubstituted C5-C10 heteroaryl, substituted or unsubstituted —C1-C6 alkyl-C6-10 aryl, substituted or unsubstituted C1-C6alkylC(O)—, substituted or unsubstituted C1-C6alkylS(O)1-2—, substituted or unsubstituted C1-C6alkylNR′C(O)— and substituted or unsubstituted C1-C6alkoxyC(NR″)—, or R3 and R4 together with the carbon atoms that they are attached to form a 5 or 6-membered carbocyclic ring; R5 and R6 are each independently selected from the group consisting of H, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C2-C6 alkenyl, substituted or unsubstituted C2-C6 alkynyl, substituted or unsubstituted C5-C10 aryl, substituted or unsubstituted C5-C10 heteroaryl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted —C1-C6 alkyl-C6-C10 aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocyclyl, —C1-C6 alkyl-heterocyclyl, substituted or unsubstituted C1-C6alkylC(O)—, substituted or unsubstituted C1-C6alkylS(O)1-2—, substituted or unsubstituted C1-C6alkylNR′C(O)— and substituted or unsubstituted C1-C6 alkoxyC(NR″)—, hydroxy, hydroxyalkyl, alkoxy, —NH(R7), —N(R7)2, —COOH, —COR7, —COOR7, —CONHR7, —CSNHR7, —S(O)R7, —S(O)2R7, —C(O)N(R7)2, —SO2N(R7)2 and —(CH2)mR8, each of which may be optionally substituted; or R5 and R6 when taken together with the nitrogen atom to which they are attached form an optionally substituted heterocycloalkyl or heteroaryl group; each R7 is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, haloalkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, heteroarylalkyl and acyl, each of which may be optionally substituted; each R8 is independently selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl and heteroaryl, each of which may be optionally substituted; R′ and R″ are each independently selected from the group consisting of H and C1-C6 alkyl; and m is an integer selected from the group consisting of 1, 2, 3, 4, 5 and 6; Ligand is a ligand, co-additive, co-former, coordinating moiety, or a compound that complexes with the compound of Formula I to form the non-covalent derivative; and a pharmaceutically acceptable salt thereof. |
