Methods and compositions for preparing noribogaine from voacangine

摘要

Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.

主权项

1. A method for preparing and purifying noribogaine which method comprises:
a) converting voacangine to 12-hydroxyibogamine-18-carboxylic acid or the carboxylic acid salt or ester thereof, wherein the indole nitrogen is optionally protected by an amino protecting group; b) optionally isolating the 12-hydroxyibogamine-18-carboxylic acid or the carboxylic acid salt, ester and/or amino protected derivative thereof; c) converting the product of step a) or b) to noribogaine; and d) isolating noribogaine.