Method for heterogeneously catalysed manufacture of carboxylic acid derivatives

摘要

#CMT# #/CMT# Process for heterogeneously catalyzed production of carboxylic acid derivatives using a reactor system containing at least a storage container, supply pipe, at least a pump and a reaction vessel, comprises applying a permanent gas stream through a supply pipe by the use of the reaction vessel, and in a reaction room, in which the heterogeneous catalyst is not filled in a closely packed manner, so that is separated by at least two filters, and both the material and the gas stream are led by the reaction room. #CMT#USE : #/CMT# The process is useful for the heterogeneously catalyzed production of carboxylic acid derivatives such as carboxylic acid-ester or -amide, e.g. esters of fatty acids, which are used as oil phase in cosmetic formulations. #CMT#ADVANTAGE : #/CMT# The process allows solvent-free processing of low- and high-viscous reaction mixtures with simultaneous possibility for easy separation and reusability of the catalyst. #CMT#DESCRIPTION OF DRAWINGS : #/CMT# The figure shows a schematic representation of a system containing a reaction vessel, storage container, pipe and pump (Drawing includes non-English language text). #CMT#BIOLOGY : #/CMT# Preferred Components: The catalyst is at least an enzyme or at least an enzyme containing microorganism. #CMT#CERAMICS AND GLASS : #/CMT# Preferred Components: The oxide and/or ceramic carriers contain Celite(RTM: Diatomaceous Earth), zeolite, silica or controlled-pore glass. #CMT#INSTRUMENTATION AND TESTING : #/CMT# Preferred Components: The enzymatic system is present heterogeneously supported on a solid material. The heterogeneous catalyst system is reused. In the storage container, vacuum is applied. #CMT#ORGANIC CHEMISTRY : #/CMT# Preferred Process: The reaction is carried out at 20-100[deg] C. Preferred Components: The enzymatic catalyst particulate is covalently or non-covalently fixed on a carrier material. The gas is air or nitrogen (both preferred), thin air, oxygen, noble gases or carbon dioxide. The carrier material exhibits an average particle size of greater than 0.5 mu m. #CMT#POLYMERS : #/CMT# Preferred Components: The solid material consists of: a polymer on basis of polyacrylate, polymethacrylate, polyvinyl styrene, styrene divinylbenzene copolymer, polypropylene, polyethylene, polyethylene terephthalate, or polytetrafluoroethylene or copolymers of these compounds or oxide and/or ceramic carriers; and an acidic or basic ion exchange resin. #CMT#EXAMPLE : #/CMT# Myristyl alcohol (329 g) and myristic acid (351 g) were tempered in a collection container (1 l) at 60[deg] C and mixed (viscosity of the mixture at 60[deg] C, approximately 6 mPas). In the bottom region of the reaction container, Novozym 435(RTM: Immobilized lipase from Candida Antarctica) (2.7 g) was added and the total reaction container was tempered at 60[deg] C. The compressed air entry was included at 0.4 l/minute. The return was tempered at 60[deg] C. The reaction process was carried out for 25 hours (where a turnover of 99.3% was achieved relative to the fatty acid) to obtain myristyl myristate.