发明名称 |
VERBESSERTES VERFAHREN ZUR HERSTELLUNG VON COPOLYMER-1 |
摘要 |
<p>The presently disclosed subject matter provides a novel method for preparing copolymer- 1. In one embodiment, a mixture of N-carboxyanhydrides (NCAs) comprising alanine, protected-glutamic acid, protected lysine, and tyrosine, and wherein glutamic acid includes a benzyl or methoxy protecting group and lysine includes a cyclic imide or Boc protecting group are treated with a polymerization initiator to initiate polymerization of the mixture of N-carboxyanhydrides and to thereby synthesize a protected copolymer- 1. The protected copolymer- 1 can then be treated with deprotecting groups and/or depolymerized to obtain a copolymer- 1 having a desired molecular weight.</p> |
申请公布号 |
DE602007003848(D1) |
申请公布日期 |
2010.01.28 |
申请号 |
DE20076003848T |
申请日期 |
2007.07.05 |
申请人 |
MOMENTA PHARMACEUTICALS INC. |
发明人 |
IYER, MANI S.;BAUER, CORINNE;OLIVER-SHAFFER, PAT |
分类号 |
C07K14/00;C08G69/10 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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