| 摘要 |
<p>The invention concerns methods and compounds capable of modulating reverse cholesterol transport in a mammal and screening methods for selecting, identifying and/or characterising compounds capable of modulating reverse cholesterol transport. The invention also concerns cells, vectors and genetic constructs used for implementing said methods, and pharmaceutical compositions for treating atherosclerosis. The inventive methods are based on the use of FXR response elements derived from the apolipoprotein Al gene promoter.</p> |
