2-Furancarboxylic acid hydrazides and pharmaceutical compositions containing the same

摘要

The present invention provides 2-furancarboxylic acid hydrazide compounds represented by General Formula (I) below, and prodrugs, physiologically acceptable salts, hydrates, solvates thereof, methods for producing them and pharmaceutical compositions containing them: wherein A is a group represented by Formula (a) or the like: (wherein either R⁴ or R⁵ represents cyano, nitro or the like, and the other represents a hydrogen atom or the like); either R¹ or R² represents a group: -D-(X)m-R⁶ or the like, and the other represents a group: -E-(Y)n-R⁷, hydrogen atom, aryl or the like; R³ is a hydrogen atom or the like; D and E independently represent aryl; X and Y independently represent O or the like; R⁶ and R⁷ independently represent alkyl, aryl, arylalkyl or the like; and m and n are independently 0 or 1, provided that the aryl is optionally substituted. Such compounds exhibit a potent antagonistic activity on glucagon receptor and are of use as preventive and/or therapeutic agents for symptoms and diseases in which glucagon is involved.