DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE ????2 ADRENERGIC RECEPTOR.

摘要

The present invention provides a compound of formula (I) wherein: R¹ is a group selected from -CH₂OH, -NHC(O)H and R² is a hydrogen atom; or R¹ together with R² form the group -NH-C(O)-CH=CH- wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R¹ and the carbon atom is bound to the carbon atom in the phenyl ring holding R²; R³ is selected from hydrogen and halogen atoms or groups selected from -SO-R⁵, -SO₂- R⁵, -NH-CO-NH₂, -CO-NH₂, hydantoino, C_1-4alkyl, C_1-4alkoxy and -SO₂NR⁵R⁶; R⁴ is selected from hydrogen atoms, halogen atoms and C_1-4alkyl groups; R⁵ is a C_1-4alkyl group or C_3-8 cycloalkyl; R⁶ is independently selected from hydrogen atoms and C_1-4alkyl groups; n, p and q are independently 0, 1 , 2, 3 or 4; m and s are independently 0, 1 , 2 or 3; r is 0, 1 or 2; with the provisos that: at least one of m and r is not 0; the sum n+m+p+q+r+s is 7, 8, 9, 10, 11 , 12 or 13; the sum q+r+s is 2, 3, 4, 5 or 6 or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.