| 主权项 |
1. A compound of formula I: or a pharmaceutically acceptable salt thereof, wherein: W is —C(O)—, —C(S)—, or —S(O)2—; Q is —C(O)—, —C(S)—, —S(O)2—, or N; X is —O—, —S—, —NR—, or N; Y is C or N; Z is C or N; R1 is hydrogen or C1-4 aliphatic, optionally substituted with one or more halogens, —OR, —SR, —N(R)2, —N(R)C(O)R, —C(O)N(R)2, —N(R)C(O)N(R)2, —N(R)C(O)OR, —OC(O)N(R)2, —N(R)SO2R, —SO2RN(R)2, —C(O)R, —C(O)OR, —OC(O)R, —C(O)OR, —S(O)R, or —SO2R; R2 is halogen, —R, —OR, —SR, —N(R)2, —N(R)C(O)R, —C(O)N(R)2, —N(R)C(O)N(R)2, —N(R)C(O)OR, —OC(O)N(R)2, —N(R)SO2R, —SO2N(R)2, —C(O)R, —C(O)OR, —OC(O)R, —S(O)R, or —SO2R, —B(OR)2, or Hy, where Hy is selected from 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein R2 is not optionally substituted benzyl; or
R1 and R2 are taken together to form an optionally substituted 4-7 membered partially unsaturated carbocyclo-, or heterocyclo-, benzo-, or 5-6 membered heteroarylo-fused ring; each R is independently hydrogen, deuterium, or an optionally substituted group selected from C1-6 aliphatic, a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring; a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; L1 is a covalent bond or a 1-6 membered straight or branched bivalent hydrocarbon chain optionally substituted with R5 and R5′; L2 is a covalent bond or a 1-6 membered straight or branched bivalent hydrocarbon chain optionally substituted with R7 and R7′; R3 is halogen, —CN, —OR, —SR, —N(R)2, —N(R)C(O)R, —C(O)RN(R)2, —C(O)N(R)S(O)2R, —N(R)C(O)N(R)2, —N(R)C(O)OR, —OC(O)N(R)2, —N(R)SO2R, —SO2N(R)2, —C(O)R, —C(O)OR, —OC(O)R, —S(O)R, —SO2R, —B(OR)2, or an optionally substituted ring selected from phenyl or 5-6 membered heteroaryl having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R4 is hydrogen or a ring selected from a 3-8 membered monocyclic saturated or partially unsaturated carbocyclic ring, a 4-8 membered monocyclic saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, phenyl, an 8-10 membered bicyclic aryl ring, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; wherein said ring is optionally substituted with n instances of R8; each of R5 and R5′ is independently —R, —OR, —SR, —N(R)2, —N(R)C(O)R, —C(O)N(R)2, —N(R)C(O)N(R)2, —N(R)C(O)OR, —OC(O)N(R)2, —N(R)SO2R, —SO2N(R)2, —C(O)R, —C(O)OR, —OC(O)R, —S(O)R, or —SO2R; or R5 and R5′ are taken together to form a cyclopropylenyl, cyclobutylenyl, or oxetanyl group; each of R7 and R7′ is independently, —R, —OR6, —SR, —N(R)2, —N(R)C(O)R, —C(O)N(R)2, —N(R)C(O)N(R)2, —N(R)C(O)OR, —OC(O)N(R)2, —N(R)SO2R, —SO2N(R)2, —C(O)R, —C(O)OR, —OC(O)R, —S(O)R, —SO2R, or —B(OR)2; or R7 and R7′ are taken together to form a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, or a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R6 is —R, —C(O)N(R)2, or —C(O)R; each R8 is independently selected from halogen, —R, —OR, —SR, —N(R)2 or deuterium; and n is 0-5. |
