发明名称 |
METHODS OF TREATING TISSUE CALCIFICATION |
摘要 |
The present invention provides a method of treating NPP1 deficiency or NPP1-associated disease such as idiopathic infantile arterial calcification (IIAC), pseudoxanthoma elasticum, vascular calcification in chronic kidney disease (VCCKD), insulin resistance, hypophosphatemic rickets, myocardial ischemia, joint calcification, angioid streaks, and ossification of the posterior longitudinal ligament of the spine. The present invention provides a method for treating tissue calcification by administering soluble NPP1 to produce a transient increase in serum pyrophosphate levels. |
申请公布号 |
WO2016100803(A2) |
申请公布日期 |
2016.06.23 |
申请号 |
WO2015US66646 |
申请日期 |
2015.12.18 |
申请人 |
ALEXION PHARMACEUTICALS, INC. |
发明人 |
QUINN, ANTHONY;HSIA, NELSON;KHAN, TAYEBA;ASKEW, KIM LYNETTE;GRABOWSKI, GREGORY;CHENG, ZHILIANG;O'NEILL, W. CHARLES |
分类号 |
A61K38/46 |
主分类号 |
A61K38/46 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|