Benzoimidazol-2-yl pyrimidine modulators of the histamine H₄receptor

摘要

Benzoimidazol-2-yl pyrimidines, purification methods for the same, and pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by H4 receptor activity, including allergy, asthma, autoimmune diseases, and pruritus.

主权项

1. A method of obtaining a purified pharmaceutically acceptable salt of a [5-(4,6-dimethyl-1H-benzoimidazol-2-yl)-4-methyl-pyrimidin-2-yl]-[3-(1-methyl-piperidin-4-yl)-propyl]-amine, comprising:
forming a hemitartrate salt of the compound of formula (2):in water to yield an aqueous hemitartrate salt solution;
seeding said aqueous solution with crystal seeds of the tetrahydrate of said hemitartrate to obtain a seeded aqueous solution; and crystallizing out of said seeded aqueous solution the solid tetrahydrate hemitartrate of formula (3):