STABLE POWDER FORMULATION CONTAINING AN ANTICHOLINGERIC AGENT

摘要

;A spray-dried powder formulation comprising particles that contain the following components i) to iii): i) anticholinergic agents, in particular at least one compound of formula 1, in which X− is a negatively charged anion, ii) at least one embedding material selected from the group consisting of mono- or disaccharides, oligosaccharides, polymers, sugar alcohols and cholesterol, and iii) an organic, physiologically acceptable, sterically demanding acid, selected from the group consisting of ascorbic acid, a monovalent, divalent or trivalent carboxylic acid, with the exception of amino carboxylic acids, to preferably fumaric acid, oxalic acid, or diacetic acid, and a fruit acid or culinary acid, preferably citric acid, tartaric acid, malic acid, lactic acid, acetic acid, α-hydroxycaprylic acid or gluconic acid.

主权项

1. A spray-dried powder formulation comprising particles that contain the following components i) to iii):
i) a compound of formula 1wherein X− is a negatively charged anion;
ii) as an embedding material lactose; iii) an organic, physiologically acceptable, sterically demanding acid selected from ascorbic acid and a mono-, di- or trivalent carboxylic acid with the exception of the aminocarboxylic acids, wherein the acid is in a concentration such that the sprayable solution has a pH of ≦4.