PROCESS OF PREPARING AQUEOUS OPHTHALMIC SOLUTION OF OLOPATADINE

摘要

An aqueous ophthalmic solution containing relatively high concentration of olopatadine in solubilized form and process for making such solution is provided. The process for preparing the aqueous ophthalmic solution comprises a step of sizing olopatadine particles, preferably by using a microfluidizer, a ball mill or a colloidal mill. The solution is useful for providing enhanced relief from symptoms of ocular allergic disorders (e.g. conjunctivitis).

主权项

1. A process for preparing an aqueous ophthalmic solution comprising at least 0.67% w/v of olopatadine or a pharmaceutically acceptable salt thereof, which process comprises preparing a mixture comprising at least two non-ionic surfactants and olopatadine or a pharmaceutically acceptable salt thereof and sizing the mixture to form a clear solution.