| 主权项 |
1. A peptide comprising elements E1-B-E2, wherein:
a) E1 is a peptide characterized by the sequence of formula (I)
X1-X2-X3-X4-X5-K-X6-X7-X8-L-X9-X10-R-I-X11 (I) wherein the peptide of formula (I) is either: i) SEQ ID NO: 1 wherein X1 and X2 are absent; X3 is an amino acid selected from the group consisting of A, C, V, P, L, I, M, F, W, R and Y; X4 is an amino acid selected from the group consisting of T, S, P, D, M and N; X5 is an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y; X6 is an amino acid selected from the group consisting of Q, E, L, M, A, D, and W; X7, X8 and X9, independently of each other, are an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y, provided that at least two of the residues X7, X8 and X9 are an amino acid selected from the group consisting of A, R, D, N, C, G, Q, E, H, L, K, M, F, S, W and Y; and X10 and X11, independently of each other, are an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y; or ii) SEQ ID NO: 2 wherein X1 is absent or is an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y; X2 is absent or is an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y; X3 is an amino acid selected from the group consisting of T, S, P, D and N; X4 and X5, independently of each other, are an amino acid selected from the group consisting of A, R, D, N, C, G, Q, E, H, L, K, M, F, S, W and Y; X6 is an amino acid selected from the group consisting of Q, E, L, M, A, D and W; X7, X8 and X9, independently of each other, are an amino acid selected from the amino acids A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y, provided that at least two of the residues X7, X8 and X9 are an amino acid selected from the group consisting of A, R, D, N, C, G, Q, E, H, L, K, M, F, S, W and Y; and X10 and X11, independently of each other, are an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y; b) B is a peptide characterized by the sequence of formula (II)
G-X12-G-X13-X14 (II) (SEQ ID NO: 3) wherein: X12 is an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y; X13 is absent or selected from the amino acids G, A and S; and X14 is absent or is an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y; and c) E2 is a peptide characterized by the sequence of formula (III)
X15-X16-X17-X18-G-X19-X20 (III) (SEQ ID NO: 4) wherein: X15 is an amino acid selected from A, R, D, N, C, G, Q, H, I, L, K, M, F, P, S, T, V, W and Y; X16 is T or V; X17 is an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y; X18 is an amino acid selected from the group consisting of A, D, N, C, G, Q, E, H, I, L, M, F, P, S, T, V, W and Y; X19 is an amino acid selected from the group consisting of A, C, V, P, L, I, M, F, W and Y; and X20 is absent or is an amino acid selected from A, R, D, N, C, G, Q, E, H, I, L, K, M, F, P, S, T, V, W and Y. |
