Transaminase Biocatalysts

摘要

The present invention relates to pyruvate: ω-amino acid transaminases isolated from a Pseudomonas species. The transaminases act on long chain amino acids and are capable of accepting substrates comprising 8 to 12 carbon atoms. The enzymes are suitable as biocatalysts for the manufacture of nylon.

主权项

1. A substantially purified and/or recombinant polypeptide comprising:
i) an amino acid sequence as provided in any one of SEQ ID NOs:1, 2 or 6 to 12, ii) an amino acid sequence which is at least 40% identical to any one or more of SEQ ID NOs:1, 2 or 6 to 12, or iii) a biologically active fragment of i) or ii), wherein the polypeptide has amino transferase activity.