BONE MORPHOGENETIC PROTEIN-2-DERIVED BIOACTIVE PEPTIDES AND THEIR PREPARING METHODS AND USES

摘要

New bone morphogenic protein-2-derived bioactive peptides and their preparing methods and uses for promoting bone generation and treating of bone defects. These bone morphogenic protein-2- derived bioactive peptides have any of the following structures: S<SUP>[P04]</SUP>KIPKASSVPTELSAISTLYLDDD, CCCCDDDS<SUP>[P04]</SUP>KIPKASSVPTELSAISTLYL or C<SUB>16</SUB>H<SUB>31</SUB>O- NH-CCCCGGGS<SUP>[P04]</SUP>-KIPKASSVPTELSAISTLYL. They are prepared by synthetic methods.