PHARMACEUTICAL COMPOSITION COMPRISING SILYMARIN FOR PREVENTION AND TREATMENT OF IRRITANT CONTACT DERMATITIS

摘要

A composition comprising silymarin is provided to inhibit irritant contact dermatitis by inhibiting increase of the thickness of ear, increase of the moisture content of the ear, increase of lymph node weight and expression of TNF-alpha. A pharmaceutical composition for preventing and treating irritant contact dermatitis comprises silymarin or main ingredients thereof such as silybin, silidianin and silicristin. The composition further comprises a pharmaceutically acceptable carrier, an excipient and a diluent. The functional cosmetics of irritant contact dermatitis comprises silymarin or main ingredients thereof such as silybin, silidianin and silicristin and is in the form of skin lotion, skin softener, skin toner, astringent, lotion, milk lotion, moisture lotion, nutritive lotion, massage cream, nutritive cream, moisture cream, hand cream, essence, nutritive essence, pack, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, emulsion, press powder, or loose powder.