The invention generally relates to recombinant human cytomegalovirus (CMV) gB proteins and immunogenic fragments thereof, which do not comprise a transmembrane (TM) domain; and comprise one or more mutations that reduce the aggregation between the monomeric trimers of gB, and/or adhesion of the monomeric trimer of gB to the host cell.
申请公布号
WO2016092460(A2)
申请公布日期
2016.06.16
申请号
WO2015IB59420
申请日期
2015.12.07
申请人
GLAXOSMITHKLINE BIOLOGICALS SA
发明人
CARFI, ANDREA;CHANDRAMOULI, SUMANA;SETTEMBRE, ETHAN C.
