摘要 |
<p>A three-step method of making a substituted dihalo aromatic acid chloride is disclosed. A substituted aromatic compound having the general formula is halogenated to produce a mixture of corresponding dihalo and trihalo aromatic compounds, where R is COOH or COOR', R' is alkyl from C1 to C6, each R1 is independently selected from alkyl or alkoxy from C1 to C6 with no more than a single R1 group in the ortho position, and n is 1 or 2. Ortho halogens are selectively dehalogenated to produce the corresponding monohalo and dihalo aromatic compounds. The dihalo aromatic compound is converted into the corresponding acid chloride.</p> |