发明名称 |
SUBSTITUTED PYRIMIDINE COMPOUNDS AS PHOSPHATIDYLINOSITOL 3-KINASE Δ INHIBITOR AND USE THEREOF |
摘要 |
The present invention belongs to the field of medicinal chemistry, and relates to substituted pyrimidine compounds as phosphatidylinositol 3-kinase (PI3K) δ inhibitor and a use thereof. In particular, the present invention provides a compound as shown by formula I or an isomer, a pharmaceutically acceptable salt, a solvate or a prodrug thereof, the preparation methods of same and pharmaceutical compositions containing these compounds and a use of these compounds or compositions for treating cancer, hyperblastosis diseases or inflammatory diseases. The compounds of the present invention have a good inhibiting activity on PI3Kδ and have a high selectivity. It is hoped that these will be therapeutic agents for cancer, hyperblastosis diseases or inflammatory diseases. |
申请公布号 |
WO2016141855(A1) |
申请公布日期 |
2016.09.15 |
申请号 |
WO2016CN75618 |
申请日期 |
2016.03.04 |
申请人 |
NANJING SANHOME PHARMACEUTICAL CO.,LTD. |
发明人 |
WANG, Yong;LIU, Xiaorong;HUANG, Dandan;ZHANG, Yan;KAI, Yumei |
分类号 |
C07D405/12;A61K31/506;A61P11/06;A61P19/02;A61P19/08;A61P27/04;A61P27/14;A61P29/00;A61P35/00;A61P35/02;A61P37/08;C07D401/12 |
主分类号 |
C07D405/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|