发明名称 |
Bifunctional peptide |
摘要 |
The present invention concerns a bifunctional peptide capable of activating collagen synthesis and inhibiting the production of matrix metalloproteinases, said peptide having a sequence comprising three peptide parts A, B and C: - the first peptide part A corresponding to a hexapeptide repeated at least three times, said part A being capable of bonding to a receptor elastin-binding protein in order to stimulate collagen synthesis, the second peptide part B corresponding to a tetrapeptide capable of acting as a competitive inhibitor of urokinase protease and of being cleaved by said protease, and, the third peptide part C corresponding to a tripeptide occupying at least one active site of the matrix metalloproteinases in order to enable inhibition of said proteinases. The present invention further concerns a cosmetic and/or pharmaceutical composition incorporating the bifunctional peptide. |
申请公布号 |
AU2013214039(B2) |
申请公布日期 |
2016.12.01 |
申请号 |
AU20130214039 |
申请日期 |
2013.01.31 |
申请人 |
Centre National de la Recherche Scientifique;Regentis International;Universite de Reims Champagne Ardenne |
发明人 |
Hornebeck, William;Attia, Joan;Lorimier, Sandrine;Antonicelli, Franck |
分类号 |
C07K4/12;A61K38/55;A61Q19/00;A61Q19/08 |
主分类号 |
C07K4/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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