| 发明名称 |
REGULATION OF SODIUM CHANNELS BY PLUNC PROTEINS |
| 摘要 |
The present invention relates to the ability of PLUNC proteins, such as SPLUNC1 and SPLUNC2, to bind to sodium channels and inhibit activation of the sodium channels. The invention further relates to methods for regulating of sodium absorption and fluid volume and treating disorders responsive to modulating sodium absorption by modulating the binding of PLUNC proteins to sodium channels. |
| 申请公布号 |
US2016159879(A1) |
申请公布日期 |
2016.06.09 |
| 申请号 |
US201514971523 |
申请日期 |
2015.12.16 |
| 申请人 |
The University of North Carolina at Chapel Hill |
发明人 |
Tarran Robert;Stutts Monroe Jack;Donaldson Scott |
| 分类号 |
C07K14/705 |
主分类号 |
C07K14/705 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide consisting essentially of the sodium channel binding domain of a PLUNC protein, or a functional fragment or homolog thereof. |
| 地址 |
Chapel Hill NC US |
