| 发明名称 |
Targeting of Cytokine Antagonists |
| 摘要 |
The present invention relates to a fusion protein, comprising a cytokine antagonist and a targeting moiety, preferably an antibody or anti-body like molecule. In a preferred embodiment, the cytokine antagonist is a modified cytokine which binds to the receptor, but doesn't induce the receptor signalling. The invention relates further to a fusion protein according to the invention for use in treatment of cancer and immune- or inflammation-related disorders. |
| 申请公布号 |
US2016159875(A1) |
申请公布日期 |
2016.06.09 |
| 申请号 |
US201414905348 |
申请日期 |
2014.07.01 |
| 申请人 |
VIB VZW ;UNIVERSITEIT GENT ;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ;UNIVERSITÉ MONTPELLIER 2 ;CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE MONTPELLIER |
发明人 |
Tavemier Jan;Zabeau Lennart;Uze Gilles;Paul Franciane;Bordat Yann;Garcin Genevieve |
| 分类号 |
C07K14/56;C07K16/28 |
主分类号 |
C07K14/56 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A fusion protein comprising a cytokine antagonist and a targeting moiety consisting of an antibody or antibody-like molecule. |
| 地址 |
Gent BE |
