发明名称 |
NON-HUMAN ANIMALS HAVING A HUMANIZED CLUSTER OF DIFFERENTIATION 274 GENE |
摘要 |
Non-human animals, methods and compositions for making and using the same, are provided, wherein said non-human animals comprise a humanization of a Cluster of Differentiation 274 (CD274) gene. Such non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous CD274 gene so that said non-human animals express a Programmed cell death ligand 1 (PD-L1) polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion). |
申请公布号 |
WO2016094481(A1) |
申请公布日期 |
2016.06.16 |
申请号 |
WO2015US64626 |
申请日期 |
2015.12.09 |
申请人 |
REGENERON PHARMACEUTICALS, INC. |
发明人 |
BUROVA, ELENA;TANG, YAJUN;LAI, KA-MAN VENUS;MURPHY, ANDREW J. |
分类号 |
C07K16/28;A01K67/027;A61K39/00;A61K39/395;A61P35/00;C07K16/22;C07K16/30 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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