Interferon-β production modulating listeria strains and methods for using same

摘要

Mutant Listeria bacteria that modulate interferon-β production are provided. The subject bacteria are characterized by having a mutation in a gene chosen from a TetR gene, a LadR gene, a VirR gene, a MarR gene a MdrL gene, a MdrT gene and a MdrM gene. The subject bacteria find use in a variety of applications, where representative applications of interest include, but are not limited to: (a) use of the subject bacteria as adjuvants; (b) use of the subject bacteria as delivery vectors for introducing macromolecules into a cell; (c) use of the subject bacteria as vaccines for eliciting or boosting a cellular immune response; etc.

主权项

1. A vaccine in a pharmaceutically acceptable formulation comprising an attenuated Listeria bacterium having a mutation which modulates the expression of a multidrug resistance transporter, wherein said attenuated Listeria bacterium modulates interferon-β production in macrophages and wherein the formulation further comprises a second agent selected from the group consisting of: an anti-neoplastic agent, a chemotherapeutic, an antiviral agent and a multiple sclerosis therapy agent.