Methods and compositions for treating fatigue associated with disordered sleep using very low dose cyclobenzaprine

摘要

The present invention relates to methods for the treatment or prevention of fatigue associated with disordered sleep, for example, in multiple sclerosis, fibromyalgia, Fabry's disease, Parkinson's disease, or traumatic brain injury, using cyclobenzaprine. The present invention further relates to a biomarker for the therapeutic effects of a cyclobenzaprine treatment.

主权项

1. A method for monitoring the effectiveness of cyclobenzaprine treatment for disordered sleep in a subject at risk of suffering from disordered sleep, who has received the cyclobenzaprine treatment, the method comprising:
a) measuring the CAP A1, A2 and A3 rates in the subject; b) generating an nCAP A2+A3 (CAPA2+A3(Norm)) value from the measurements in a); and c) monitoring the effectiveness of the cyclobenzaprine treatment for disordered sleep wherein the cyclobenzaprine treatment is effective when the CAPA2+A3(Norm) value generated in step b) is less than or equal to a threshold CAPA2+A3(Norm) value generated in subjects suffering from disordered sleep who have received a placebo.