发明名称 |
Avian transgenesis using a chicken ovalbumin gene region |
摘要 |
The present invention provides isolated and recombinant avian nucleic acid molecules comprising at least one avian MAR and an avian nucleic acid sequence encoding an ovalbumin transcriptional regulatory region. The isolated nucleic acid of the present invention is useful for reducing chromosomal positional effects upon the transcription of a transgene operably linked to the ovalbumin transcriptional regulatory region and transfected into a recipient avian cell The recombinant nucleic cid molecules of the present invention may further comprise a polyadenylation signal sequence or an avian 3' domain, and optionally, an internal ribosome entry site for expression of an operably linked heterologous nucleic acid insert in a transfected avian cell.
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申请公布号 |
US2006130170(A1) |
申请公布日期 |
2006.06.15 |
申请号 |
US20030733042 |
申请日期 |
2003.12.11 |
申请人 |
LEAVITT MARKLEY C;RAPP JEFF;IVARIE ROBERT;KARNUAH ARTHUR |
发明人 |
LEAVITT MARKLEY C.;RAPP JEFF;IVARIE ROBERT;KARNUAH ARTHUR |
分类号 |
A01K67/027;C07H21/04;C07K14/77;C07K16/00;C12N5/06;C12N15/85;C12P21/06;C12Q1/68 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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