l)-3-(trifluoromethyl phenylÜ benzamide solubilizeModified release of 4-methyl-3-[[4-(3-pyridinyl)-2- pyrimidinyl]amino]-N-5-(4-methyl-IH-imidazol-I-yd using organic acids

摘要

Soluble pharmaceutical compositions of nilotinib or a pharmaceutically acceptable salt thereof were invented using one or more organic acids that function as a solubilizing agent, increasing the bioavailability of nilotinib and supressing the food effect associated with certain compositions of nilotinib. The pharmaceutical compositions are in the form of solid oral dosage forms, including capsules and tablets.