TUNGSTATE TREATMENT OF THE DYSBIOSIS ASSOCIATED WITH GASTROINTESTINAL INFLAMMATION

摘要

The present invention provides compositions of therapeutic agents and methods of use for reducing and/or treating gastrointestinal inflammation. In particular aspects, the tungstate salts described herein and pharmaceutical compositions thereof inhibit the activity of one or a plurality of anaerobic respiratory enzymes in facultative anaerobic bacteria such as, for example, Enterobacteriaceae, that can exacerbate inflammation. In particular embodiments, the present invention provides compositions of therapeutic agents for treating gastrointestinal inflammation, as well as methods for treating or preventing gut microbial imbalance due to an increase in the abundance of intestinal Enterobacteriaceae.

主权项

1. A method for treating dysbiosis in a subject having gastrointestinal inflammation, the method comprising administering to the subject a therapeutically effective amount of a tungstate salt.