Host cell and method for the recombinant expression of a soluble interferon

摘要

The invention relates to biotechnology, particularly to a host cell and a method for the recombinant expression of a soluble interferon.According to the invention, a host cell for recombinant expression of a mammalian interferon protein is claimed, said cell comprising: (a) a functional endogenous trxB gene and (b) an inactivated endogenous gor gene, the invention further relates to the use of such host cells for the recombinant expression of an interferon protein and to a method for the recombinant expression of a soluble interferon in a host cell.