PCSK9 QUANTIFICATION BY IMMUNODETECTION

摘要

The present disclosure relates to, among other things, systems for detecting the level of specific lipoprotein-bound level of PCSK9, and optionally free PCSK9, lipoprotein or portions thereof and/or PCSK9 unbound lipoproteins present in a biological sample. The present invention also relates to methods of assessing the level of specific lipoprotein-bound level of PCSK9, and optionally free PCSK9, Apo B and/or PCSK9 unbound lipoproteins present in a biological sample, determining whether a subject is at increased risk for cardiovascular disease and monitoring the risk for developing cardiovascular disease.

主权项

1. A gel electrophoresis system for detecting a level of PCSK9 bound and/or unbound to lipoprotein particles present in a biological sample comprising:
a gel substrate to receive a biological sample; and an anti-PCSK9 antibody, at least one anti-lipoprotein antibody, or both.