摘要 |
The present invention provides compounds of formula I,;
wherein the variables R1, R2, R5 and b are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed. |
主权项 |
1. A compound of formula (I)or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer, wherein:
R1 is selected from hydrogen, —CH3, —CH2F, —CHF2, —CF3, or —CH2OCH3; R2 is —(C(R3a)(R3b))m—(C3-C6)cycloalkyl or —(C(R3a)(R3b))m-(4- to 10-membered) heterocycloalkyl having one to three heteroatoms independently selected from N, O or S, wherein said N is optionally substituted with R4; and wherein each available carbon position of said (C3-C6)cycloalkyl moiety or said (4- to 10-membered)heterocycloalkyl moiety is optionally substituted with one to two R6; R3a and R3b are each independently hydrogen, fluoro, or (C1-C6)alkyl; wherein said (C1-C6)alkyl is optionally substituted with one to three fluoro; R4 is selected from (C1-C6)alkyl, (C1-C6)alkylcarbonyl, (C3-C6)cycloalkylcarbonyl or (C1-C6)alkylcarbonyl(C1-C6)alkyl; wherein said (C1-C6)alkyl moiety, said (C1-C6)alkylcarbonyl moiety and said (C1-C6)alkylcarbonyl(C1-C6)alkyl moiety are optionally substituted with one to three fluoro; R5 at each occurrence is independently halogen, (C1-C3)alkyl, and (C1-C3)alkoxy, wherein said (C1-C3)alkyl moiety and said (C1-C3)alkoxy are optionally substituted with one to three fluoro; R6 at each occurrence is independently halogen, —OH, —CN, (C1-C6)alkyl, and (C1-C6)alkoxy, wherein said (C1-C6)alkyl or (C1-C6)alkoxy is optionally substituted with one to three fluoro; m is 0, 1, or 2; and b is 0, 1, 2, 3, 4, or 5. |