| 主权项 |
1. A method for treating beta amyloid (Aβ) peptides aggregation-associated diseases and preventing development and progression of said diseases due to increased beta-amyloid aggregates-induced neurotoxicity by administering carbazole-based fluorophores comprising a formula S series: said method comprising: binding said carbazole-based fluorophores to Aβ peptides, oligomers and/or fibrils thereof; inhibiting the growth and/or aggregation of said Aβ peptides, oligomers and/or fibrils upon said binding; and protecting neuronal cells against neurotoxic activities of the Aβ oligomers and/or fibrils; wherein Ar is a heteraromatic ring selected from the group consisting of pyridinyl, substituted pyridinyl, quinolinyl, substituted quinolinyl, acridinyl, substituted acridinyl, benzothiazolyl, substituted benzothiazolyl, benzoxazolyl, and substituted benzoxazolyl; R1 is a radical selected from the group consisting of polyethylene glycol chain, alkyl, substituted alkyl, peptide chain, glycosidyl, and C(O)NHCH((CH2CH2O)2CH3)2; R2 is selected from the group consisting of ethenyl, ethynyl, azo and azomethinyl, R3 is a radical selected from the group consisting of HO-alkyl, alkyl-COOalkyl, alkyl-CONH2, alkyl-CONHalkyl, polyethylene glycol chain; X is an anion selected from the group consisting of F, Cl, Br, I, HSO4, H2PO4, HCO3, tosylate, and mesylate; Y is selected from the group consisting of H, F, Cl, OH, and OCH3, and wherein when Y is H, R3 cannot be HO-alkyl. |
