Disclosed are anthranilic amide derivatives having the formula. Compositions are disclosed that include the anthranilic amide derivatives and the use of the anthranilic amide derivatives for the manufacture of a medicament. Further disclosed are methods of inhibiting or treating cancer, inhibiting or reversing an epithelial to mesenchymal cellular transition, and/or inhibiting MEK1/2 and/or MEK 5 enzymatic activity in a subject by administering to the subject an effective amount of a disclosed anthranilic amide derivative.
申请公布号
EP3043790(A1)
申请公布日期
2016.07.20
申请号
EP20140843462
申请日期
2014.09.11
申请人
THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND;DUQUESNE UNIVERSITY OF THE HOLY GHOST
发明人
CHAKRABARTY, SURAVI;FLAHERTY, PATRICK T.;MONLISH, DARLENE;CAVANAUGH, JANE E.;BUROW, MATTHEW E.;ELLIOTT, STEVEN;HOANG, VAN T.