SYNTHESIS AND FORMULATIONS OF PORPHYRIN COMPOUNDS

摘要

Provided herein, inter alia, are methods of synthesizing and formulating porphyrins, including manganese containing porphyrins. Also provided herein are pharmaceutical compositions and crystals of porphyrins achieved using the methods described herein.

主权项

1. A method for synthesizing a substituted porphyrin having the formula: wherein R1 is substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl, said method comprising: (i) contacting a pyrrole with an R1-substituted aldehyde, wherein said contacting is performed in a solvent system comprising a positive azeotrope; (ii) allowing said pyrrole to react with said R1-substituted aldehyde in said solvent system under azeotropic distillation conditions, thereby forming a substituted-porphyrinogen; and (iii) oxidizing said substituted-porphyrinogen, thereby synthesizing a substituted porphyrin having formula (I).