| 主权项 |
1. An amphiphilic pressure sensitive adhesive composition suitable for securing a medical device to human skin, wherein the pressure sensitive adhesive comprises an amphiphilic copolymer of at least one hydrophobic acrylic monomer or oligomer; at least one hydrophilic or amphiphilic monomer or oligomer; and a crosslinker, wherein the hydrophilic or amphiphilic monomer or oligomer is selected from acrylamides, N-alkylacrylamides, N,N-dialkylacrylamides, N-alkylaminoalkylacrylamides, methacrylamides, amino methacrylates, N-alkylamino acrylates, N,N-dialkylamino acrylates, N-alkylamino methacrylates, acrylamido alkylsulfonic acid and its salts, N-vinylpyrrolidones, N-vinylcaprolactams, and combinations thereof; and the crosslinker is selected from polybutadiene dimethacrylate, trimethylolpropane trimethacrylate, and ethylene glycol dimethacrylate, wherein the crosslinker is present at 0.2 to 0.5 wt %; such that the amphiphilic copolymer:
a) is crosslinked in solution and is castable after crosslinking, b) does not dissolve in aqueous medium, c) absorbs less than 10% of its weight in the presence of water or moisture, d) is peelable from human skin and does not leave residue, e) remains adherent to skin under wet conditions, f) has a glass transition temperature below 25° C., and g) wherein the 180-deg peel strength of the adhesive to Stainless Steel plate tested per ASTM D3330 is below 20 N/in with minimal residue on the plate. |
