发明名称 |
CHIMERIC ANTIGEN RECEPTORS |
摘要 |
Disclosed herein are chimeric antigen receptors (CARs) comprising an intracellular segment comprising an interleukin receptor chain, a JAK-binding motif, a Signal Transducer and Activator of Transcription (STAT) 5 association motif and/or a CD3ζ intracellular signaling domain comprising an exogenous STAT3 association motif, as well as cells and 5 compositions comprising said CARs and uses thereof. |
申请公布号 |
WO2016127257(A1) |
申请公布日期 |
2016.08.18 |
申请号 |
WO2016CA50126 |
申请日期 |
2016.02.11 |
申请人 |
UNIVERSITY HEALTH NETWORK;TAKARA BIO INC. |
发明人 |
TANAKA, Shinya;HIRANO, Naoto;KAGOYA, Yuki |
分类号 |
C07K19/00;A61K35/12;A61K38/16;A61K39/00;A61P35/00;A61P37/04;C07K5/107;C07K14/47;C07K14/705;C07K14/715;C12N5/10;C12N15/62 |
主分类号 |
C07K19/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|