| 发明名称 |
OPHTHALMIC EMULSION COMPOSITION OF CYCLOSPORINE |
| 摘要 |
The invention relates to an ophthalmic emulsion composition of cyclosporine in the form of an oil-in-water emulsion. The emulsion remains stable at 25° C. for at least 6 months or at 45° C. for at least 45 days. The composition is useful for treating a dry eye condition or glaucoma, and preferably for increasing tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sicca. |
| 申请公布号 |
US2016271059(A1) |
申请公布日期 |
2016.09.22 |
| 申请号 |
US201514659345 |
申请日期 |
2015.03.16 |
| 申请人 |
Gavis Pharmaceuticals |
发明人 |
Trehan Aman;Nayar Bala Chandran |
| 分类号 |
A61K9/107;A61K47/44;A61K38/13 |
主分类号 |
A61K9/107 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An ophthalmic oil-in-water emulsion composition consisting essentially of:
(a) cyclosporine A in an amount of about 0.001% to about 0.1% by weight; (b) an oil comprising castor oil, sesame oil or a combination in an amount of about 0.01% to about 1.5% by weight; (c) at least one anionic surfactant; and (d) water, wherein, the emulsion is devoid of a non-ionic surfactant. |
| 地址 |
Somerset NJ US |
