OPHTHALMIC NANOPARTICULATE FORMULATION OF A CYCLOOXYGENASE-2 SELECTIVE INHIBITOR
摘要
<p>The present invention is directed to a novel pharmaceutical composition suitable for ophthalmic use comprising nanoparticles dispersed in a liquid dispersion medium, wherein said nanoparticles comprise a cyclooxygenase-2 selective inhibitor having adsorbed on the surface thereof at least one surface stabilizer. The ophthalmic formulation of the present invention is stable, non-irritating and sufficiently bioavailable. The invention also encompasses a process for making as well as a kit for preparing the novel ophthalmic formulation.</p>
申请公布号
WO2006062875(A1)
申请公布日期
2006.06.15
申请号
WO2005US43858
申请日期
2005.12.05
申请人
MERCK & CO., INC.;PANMAI, SANTIPHARP;ALANI, LAMAN, L.