Surfactant-copolymer complexes useful for sustained drug release

摘要

The invention discloses a surfactant-copolymer complex for delivery of hydrophobic compounds in sustained release; wherein the surfactant is a non-ionic surfactant; and copolymer is poly (maleic acid-alt-vinyl methyl ether). The present invention also provides a process for preparation of the surfactant-copolymer complex.

主权项

1. A hydrophobic compound loaded surfactant-copolymer complex for sustained and controlled release of hydrophobic compounds, the surfactant-copolymer complex comprising a hydrophobic compound in the range of 0.1% to 10% (by weight), a surfactant in the range of 0.1% to 30% (by weight) and a mucoadhesive copolymer in the range of 0.1% to 30% (by weight) and the remaining being a solvent, wherein the complex is constituted to perform the sustained release of the hydrophobic compounds over a period of 13-23 hours, prepared by a process comprising the steps of:
a) dispersing mucoadhesive copolymer in solvent in a ratio ranging between 1% to 40% to obtain turbid solution of mucoadhesive copolymer; b) dissolving the hydrophobic compound in surfactant in a ratio ranging between 1% to 50% (weight of hydrophobic compound by weight of the surfactant) at temperature in the range of 10° C. to 80° C. to obtain hydrophobic compound-surfactant mixture; c) adding hydrophobic compound-surfactant mixture as obtained in step (b) in water to obtain surfactant solution loaded with hydrophobic compound; d) adding surfactant solution loaded with hydrophobic compound as obtained in step (c) to the turbid solution of mucoadhesive copolymer as obtained in step (a) to obtain hydrophobic compound loaded surfactant-copolymer complex.