METHOD FOR THE IDENTIFICATION OF GENE REGULATION TARGETS

摘要

A method arising from knocking down the components of the splicing machinery on alternative splicing events relevant for cell proliferation and apoptosis and using this information to reconstruct a network of functional interactions. The network accurately captures known physical and functional associations and identifies new ones, revealing remarkable regulatory potential of core spliceosomal components. It can be used to infer targets of alternative splicing regulation and of drugs directed to diseases associated to altered splicing events.