摘要 |
PROBLEM TO BE SOLVED: To provide a method for obtaining a collagen membrane, capable of holding sufficient flexibility and elasticity for application to surgery, especially having high tension strength and tear strength.SOLUTION: A production method of a collagen material comprises: a) a step for preparing an acidic natural or modified collagen solution; b) a step for adding an aldehyde crosslinking agent having no reactivity at acidic pH; c) a step for molding or casting the collagen solution; d) a step for processing with ammonia gas, thereby coagulating and crosslinking the collagen solution; e) and a step for removing surplus ammonia, and obtaining the collagen material by drying. The solution used in the step a contains an acidic collagen of 0.05-3 mass%, and coagulation and crosslinking of the collagen solution in the step d) are processed by the ammonia gas, at least 24 hours, preferably.SELECTED DRAWING: None |