发明名称 |
EPSTEIN-BARR VIRUS VACCINES |
摘要 |
Vaccines are provided that elicit neutralizing antibodies to Epstein-Barr virus (EBV). Some vaccines comprise nanoparticles that display envelope proteins from EBV on their surface. The nanoparticles comprise fusion proteins comprising a monomeric subunit of a self-assembly protein, such as ferritin, joined to at least a portion of an EBV envelope protein. The fusion proteins self-assemble to form the envelope protein-displaying nanoparticles. Such vaccines can be used to vaccinate an individual against infection by different types of Epstein-Barr viruses as well as Epstein-Barr viruses that are antigenically divergent from the virus from which the EBV envelope protein was obtained. Also provided are fusion proteins and nucleic acid molecules encoding such proteins. |
申请公布号 |
US2016303224(A1) |
申请公布日期 |
2016.10.20 |
申请号 |
US201415028655 |
申请日期 |
2014.10.10 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN |
发明人 |
KANEKIYO Masaru;NABEL Gary J.;COHEN Jeffrey;BU Wei |
分类号 |
A61K39/245;C07K16/08;C07K14/195;C12N7/00;C07K14/005;C07K14/00 |
主分类号 |
A61K39/245 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Bethesda MD US |