NUCLEIC ACID BINDING POLYPEPTIDES

摘要

We describe the use of a nucleic acid binding polypeptide capable of binding to one or more of telomeric, G-quadruplex, or G-quartet nucleic acid as an inhibitor of enzymatic activity, including a telomerase activity, a polymerase activity, an integrase activity and a gp120 activity. Telomerase assays as well as methods of identifying molecules capable of interacting with telomeric, G-quadruplex, or G-quartet nucleic acid are also described.