| 摘要 |
<p> An orally-administrable pharmaceutical formulation is provided comprising a lipophilic compound and a pharmaceutically-acceptable carrier or excipient encased so as to prevent release of the lipophilic compound for between about 10 minutes and 1 hour after administration. The lipophilic compound may be Coenzyme Q10, vitamin A, vitamin E, vitamin K or derivatives of these. The lipophilic compound is preferably CoQ10 encased by a gelatin capsule and a coating that may be a water soluble polymer such as a cellulose ether, polyvinylpyrrolidone or polyethylene glycol or a pH-sensitive polymer such as hydroxypropylmethylcellulose phthalate or polyvinyl acetate phthalate. Also provided is a method of preparing the pharmaceutical formulation and a method of administering the pharmaceutical formulation so that release of the lipophilic compound is prevented for between about 10 minutes and 1 hour after administration. The pharmaceutical formulation of the invention may be particularly useful when administered to treat or prevent congestive heart failure.</p> |
