发明名称 |
TNFSF SINGLE CHAIN MOLECULES |
摘要 |
PROBLEM TO BE SOLVED: To provide single-chain fusion proteins comprising at least three TNF cytokine domains which allow efficient recombinant manufacturing combined with good stability concerning aggregation.SOLUTION: The present invention relates to single-chain fusion proteins comprising three soluble TNF superfamily (TNFSF) cytokine domains and to nucleic acid molecules encoding these fusion proteins. The fusion proteins are substantially non-aggregating and suitable for therapeutic, diagnostic and/or research applications. The present invention further relates to nucleic acid molecules encoding fusion proteins described herein, and to cells or non-human organisms transformed or transfected with the nucleic acid molecules described herein. |
申请公布号 |
JP2014230545(A) |
申请公布日期 |
2014.12.11 |
申请号 |
JP20140177736 |
申请日期 |
2014.09.02 |
申请人 |
APOGENIX GMBH |
发明人 |
OLIVER HILL;CHRISTIAN GIEFFERS;MEINOLF THIEMANN |
分类号 |
C12N15/09;A61K31/7088;A61K38/00;A61K48/00;A61P3/00;A61P19/02;A61P25/00;A61P29/00;A61P31/00;A61P35/00;A61P37/06;C07K14/525;C07K14/705;C07K16/00;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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